Four teams are on byes this week, and injuries have reshaped the entire New York Giants receiving corps. Those are some of the obstacles you'll face when setting up your lineups this week.
Don't despair because there are options. Here are several suggestions that could help you determine who to start in Week 6 of your fantasy football league.
-- Jacoby Brissett, Indianapolis at Tennessee
Brissett has taken advantage of favorable matchups this season, using both his arm and abilities to run the ball to his advantage. The Titans have given up the third most fantasy points per game (FPPG), as well as 13 total TDs to opposing QBs.
-- Deshaun Watson, Houston vs. Cleveland
Watson led QBs in fantasy points scored in each of the past two weeks. He's scored 10 total TDs and thrown one interception during that span. Watson is a mobile QB who's averaged just under 36 rushing yards per game and faces a Browns defense that's yielded the fourth most FPPG to opposing QBs.
-- Kirk Cousins, Washington vs. San Francisco
In his last two games before his Week 5 bye, Cousins threw five TDs and no interceptions. The week off should benefit Cousins' receiving targets like Jamison Crowder, Josh Doctson and Jordan Reed, who had been nursing injuries. The 49ers have given up an average of 321 passing yards to QBs over the past three weeks.
-- Elijah McGuire, NY Jets vs. New England
With both Matt Forte and Bilal Powell possibly out this week, McGuire will be the Jets' primary back against a Patriots team giving up the most FPPG to RBs. McGuire can catch the ball out of the backfield, and the Pats have given up the most receiving TDs to RBs.
-- Marshawn Lynch, Oakland vs. LA Chargers
While Lynch's declining snaps played percentage is concerning, he still leads Raiders RBs in carries by a wide margin. The Chargers give up 5 yards per rushing attempt as well as the most total rushing yards to RBs, who have averaged 151 yards per game.
-- Marvin Jones, Detroit at New Orleans
Jones led Lions receivers with eight targets, five catches and 64 receiving yards in Week 5. The Saints have given up the fifth highest average overall passing yards per game, and the highest average receiving yards per game to WR2s.
-- Adam Thielen, Minnesota vs. Green Bay
Vikings WR Stefon Diggs injured his groin in Week 5. Monitor his progress. If he's limited, Thielen may see the most targets among Vikings receivers in Week 6 against the Packers, who surrendered three TDs to WRs in Week 5.
-- John Brown, Arizona vs. Tampa Bay
The Buccaneers have given up the most FPPG to WRs. When healthy, John Brown is the Cardinals' most explosive receiver behind Larry Fitzgerald. Tampa Bay's defense has been riddled with injuries, yielding 309 passing yards per game, second most in football.
-- A.J. Derby, Denver vs. NY Giants
Derby was targeted six times, caught four passes for 75 yards, and made a one handed grab for a TD in his last game before his Week 5 bye. The Giants have given up at least one TD to a tight end in each game this season.
-- Ryan Griffin, Houston vs. Cleveland
Griffin has averaged five targets per game over the past three weeks. The Browns have given up the most receptions and second most FPPG to tight ends.
-- Eli Manning, NY Giants at Denver
The Giants lost four WRs in Week 5, (two of them for the season). They limp into Denver against the Broncos' shutdown defense that's allowing the 10th lowest average passing yards per game.
-- Jared Goff, LA Rams at Jacksonville
Goff faces a Jaguars defense that forced Ben Roethlisberger to throw five interceptions in Week 5, and has given up the fewest FPPG to QBs.
-- Jonathan Stewart, Carolina vs. Philadelphia
Stewart is coming off of a brutal 18 carry, 21 yard Week 5 performance and is up against an Eagles defense that allows just 63 rushing yards per game, and the sixth fewest FPPG to RBs.
-- NY Giants Running Backs, vs. Denver
Whether Orleans Darkwa is healthy enough to play, or if it's Wayne Gallman carrying the ball for the Giants, anyone trying to run against the Broncos defense will have a hard time. They're allowing just 2.4 yards per carry and 51 rushing yards per game.
-- DeVante Parker, Miami at Atlanta
The Dolphins are hinting that Parker, who injured his ankle in Week 5, may play in Week 6, however their overall offense looks terrible. They weren't able to move the ball in a favorable matchup against the Titans in Week 5, and all Dolphins receivers should be downgraded this week against an improved Falcons defense.
-- Tyreek Hill, Kansas City vs. Pittsburgh
Although he returned a punt for a TD, Hill had a pedestrian four catches for 68 yards in Week 5. This week, he faces a Steelers team that has yielded the lowest average passing yards per game and the fewest FPPG to WRs. He still has big play potential, but will be severely challenged in Week 6.
-- Eric Ebron, Detroit at New Orleans
Tight ends have just 13 receptions against the Saints. Ebron has caught just five passes on 15 targets over the past three weeks, and is droppable in most leagues.