MINNEAPOLIS (AP) -- Carlos Santana hit two of Cleveland's five home runs and Danny Salazar continued his strong second-half stretch in the Indians' 8-1 victory over the Minnesota Twins on Tuesday night.
Santana, Jason Kipnis and Edwin Encarnacion all hit solo homers off Bartolo Colon (4-10) as Cleveland won its fifth straight overall and stayed unbeaten in eight games in Minnesota this season. Austin Jackson added a three-run shot and Santana homered from both sides of the plate for the Indians, who have outscored the Twins 56-16 at Target Field this season.
Salazar (5-5) cruised through seven innings, surrendering one run and three hits. He struck out 10 while running his mark to 2-0 with a 1.39 ERA and 46 strikeouts in 32 1/3 innings in five starts since coming off the disabled list on July 22.
- Santana, Indians power past Twins 8-1
- WATCH: Twins' Buxton robs homer in center field
- Cleveland series critical for resurgent Twins
- StaTuesday: Cuddyer carved out a niche with Twins
- Twins Final Pitch: Minnesota finishes trip 4-1
Colon gave up three runs and seven hits in five innings. The 44-year-old right-hander walked four for just the second time in four seasons.
Santana and Encarnacion have always enjoyed hitting in Minnesota's unexpectedly power-friendly park. Santana has 18 homers this season overall and tied the most homers by a Twins' opponent with 14 in 66 career games at Target Field.
Encarnacion hammered his 27th homer of the year to the back row in the second deck in left field for his third straight game with a homer. He has five in the past five games overall and 12 in his 31 games in Target Field.
Salazar finished a season-high seven innings for the third time in his past five starts. Byron Buxton's RBI single in the second inning opened the scoring, but Salazar retired 13 of the final 14 batters he faced.
Indians: LHP Andrew Miller (right knee patella tendinitis) will make a one-inning rehab appearance in Triple-A on Wednesday and be activated on Friday before Cleveland begins a series in Kansas City. . OF Lonnie Chisenhall (right calf strain) played in a rehab game with Triple-A Columbus on Tuesday. He's been out since July 11. Manager Terry Francona said the team wants Chisenhall to play both corner outfield spots before his return.
Twins: LHP Hector Santiago was pulled off his rehab assignment for upper thoracic back pain. The team is doing more tests to discover why Santiago hasn't been able to return to full strength yet, as well as looking at other possible sources of injury. . LHP Glen Perkins completed his rehab assignment at Double-A Chattanooga after pitching on back-to-back days. The team will take the next few days to decide on the next step with its former closer, who hasn't pitched in a game since April 10, 2016.
The Indians turn to RHP Carlos Carrasco (11-5, 3.83 ERA) on Wednesday as the Twins counter with RHP Kyle Gibson (6-9, 6.02). Carrasco is coming off an eight-inning, two-hit victory against Tampa Bay in his last outing. He beat Minnesota in Cleveland earlier this season with one run allowed and four hits in 6 1/3 innings. Gibson is 0-2 in three starts against the Indians this season, with seven runs allowed in 16 innings.