Miguel Sanó hit a three-run homer, leading the Minnesota Twins over Baltimore 3-2 Wednesday for a three-game sweep of the major league-worst Orioles.

Michael Pineda (3-2) allowed one run and three hits over six innings in his first start since May 13 following a trip to the injured list caused by a thigh abscess. He struck out eight and walked two, and fell behind in the first on Trey Mancini's 11th home run.

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Minnesota rallied to win for the sixth time in seven games and extend its winning streak to a season-high four. The Twins have beaten Baltimore 15 straight times since March 31, 2018.

The Orioles have lost nine straight, the longest skid since dropping 10 in a row from June 12-21, 2019, and have been outscored 72-39 during the slide. Baltimore has lost 16 of its past 18, falling to 17-32.

Jorge López (1-6) dropped to 0-4 in his past seven starts, giving up three runs and four hits in a season-high six innings. López has received one or no runs of support in eight of nine starts this season.

Mancini, who has 42 RBIs, began the day tied with Toronto’s Vladimir Guerrero Jr. for the major league lead.

Sanó homered with two outs in the sixth following Max Kepler's single and Nelson Cruz's walk. The 426-foot drive to center was Sanó's ninth homer and gave Minnesota home runs in 12 straight home games.

Maikel Franco hit an RBI double in the ninth off Hansel Robles, who earned his third save in four chances.

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ROSTER MOVE

Baltimore RHP Dean Kremer (0-5, 6.87) was optioned to Triple-A Norfolk. Manager Brandon Hyde said LHP Keegan Akin, who pitched three innings of relief Tuesday, will start Sunday and RHP Dillon Tate (left hamstring strain) is to be recalled from his rehab assignment Thursday. Kremer allowed nine earned runs in seven innings over his past two starts, including five runs in four innings Tuesday. He also threw two wild pitches with the Twins scoring on each.

TRAINER'S ROOM

Orioles: OF Austin Hays (left hamstring strain) was placed on the 10-day injured list, retroactive to May 24, and OF Ryan McKenna was recalled from Triple-A Norfolk. … OF/1B Ryan Mountcastle (left hand) did not play.

Twins: IF/OF Luis Arraez (right shoulder strain) was placed on the 10-day injured list retroactive to May 24. … CF Byron Buxton, out since May 7 with a right hip strain, has been having trouble decelerating when running and a rehab stint this weekend is now unlikely. … RHP Shaun Anderson (left quad strain) threw a bullpen session without issue and will join Triple-A St. Paul Friday for a rehab assignment.

UP NEXT

Orioles: Open a four-game series at the White Sox on Thursday with LHP Bruce Zimmermann (2-3, 5.59) to face Chicago’s RHP Dylan Cease (2-1, 3.18).

Twins: RHP Randy Dobnak (1-3, 5.75) gets the start Friday as Minnesota opens a weekend home series vs. Kansas City.