NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks.
Here are the lines for every Week 4 matchup at DraftKings Sportsbook as of Sept. 28.
(All times ET)
2025 NFL Week 4 Odds
THURSDAY, SEPT. 25
Spread: Seahawks -1.5 (SEA covers)
Total O/U: 43.5 (Under hits)
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SUNDAY, SEPT. 28
Spread: Vikings -2.5
Moneyline: Vikings -142, Steelers +120
Total O/U: 41.5
Spread: Falcons -2.5
Moneyline: Commanders +120, Falcons -142
Total O/U: 43.5
Spread: Bills -14.5
Moneyline: Bills -1450, Saints +850
Total O/U: 48.5
Spread: Lions -10
Moneyline: Lions -575, Browns +425
Total O/U: 44.5
Spread: Patriots -5.5
Moneyline: Patriots -245, Panthers +200
Total O/U: 42.5
Spread: Chargers -6
Moneyline: Chargers -290, Giants +235
Total O/U: 43.5
Spread: Eagles -3.5
Moneyline: Eagles -185, Bucs +154
Total O/U: 43.5
Spread: Texans -7
Moneyline: Texans -410, Titans +320
Total O/U: 39.5
Spread: Rams -3.5
Moneyline: Rams -192, Colts +160
Total O/U: 49.5
Spread: 49ers -3.5
Moneyline: 49ers -185, Jaguars +154
Total O/U: 46.5
Spread: Ravens -2.5
Moneyline: Ravens -148, Chiefs +124
Total O/U: 48.5
Spread: Raiders -1.5
Moneyline: Bears +100, Raiders -120
Total O/U: 47.5
Spread: Packers -7
Moneyline: Packers -345, Cowboys +275
Total O/U: 47.5
MONDAY, SEPT. 29
Spread: Dolphins -2.5
Moneyline: Dolphins -155, Jets +130
Total O/U: 45.5
Spread: Broncos -7.5
Moneyline: Broncos -520, Bengals +390
Total O/U: 44.5
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