"With Liz Warren, it could go either way," he said. "She could feel like she is left out and everyone is going to be punching up and attacking her constantly," he continued, referring to the other candidates featured the first night - June 26 in Miami.
"Or, she could shine and she could really come out - and the media [would] all say Liz Warren obviously cleaned up in that first debate," the "Watters' World" host added.
Warren is scheduled to face-off against Sens. Cory Booker, D-N.J., Amy Klobuchar, D-Minn., Reps. Tim Ryan, D-Ohio, and Tulsi Gabbard, D-Hawaii., former Reps. Beto O'Rourke, D-Texas and John Delaney, D-Md., Washington Gov. Jay Inslee, former Secretary of Housing and Urban Development Julian Castro and New York City Mayor Bill de Blasio.
That leaves current frontrunner and former Vice President Joe Biden debating Sens. Bernie Sanders, I-Vt., Kamala Harris, D-Calif., Kirsten Gillibrand, D-N.Y, Michael Bennet, D-Colo., Rep. Eric Swalwell, D-Calif., former Colorado Gov. John Hickenlooper, South Bend, Ind. Mayor Pete Buttigieg, entrepreneur Andrew Yang and author Marianne Williamson on the second evening's dais.
Watters said he predicted the second night's forum to be a "hot debate."
"I don't know how they will put them next to each other. It's going to get ugly. There are not a lot of lower-tier candidates for them to attack. Do you all go after Biden, or do you go after Bernie?" he asked.
The candidates' order was drawn Friday at Rockefeller Center - the New York home of NBC, the DNC's media partner for the event.