Northam tweeted that a member of his staff tested positive for the virus Wednesday evening. Northam and his wife Pamela discovered Thursday that they too had the virus.
"Pam is experiencing mild symptoms, and I am asymptomatic. Per @VDHgov guidelines, we will isolate at home for 10 days and then reevaluate our symptoms," Northam tweeted Friday morning.
While many offered their well-wishes to the couple, the Trevor Noah-hosted program invoked last year's "blackface" controversy that threatened to sink Northam's governorship.
"More evidence that coronavirus disproportionately affects Black people," read a post from the show's official Twitter account.
That quip was a not-so-subtle reference to the furor that broke when Northam's page in his medical school yearbook showed a photograph of two men, one wearing blackface and the other wearing a Ku Klux Klansman's hood.
Northam initially apologized for the image, then reversed course and denied wearing the offensive costumes but admitted that he did dress up as Michael Jackson for a dance contest.
Later Friday, President Trump chided Northam during a campaign event for Black voters in Atlanta, where he mocked the Virginia governor for almost demonstrating the moonwalk during his infamous press conference.