The year that just ended was a sad one for fans of "The Mary Tyler Moore Show,’" one of the most popular situation comedies of the 1970s.

Cast member Betty White, known for her role as Sue Ann Nivens on the series, died Friday at age 99, just 18 days before her 100th birthday.

White’s death made her the fourth member of the "MTM" cast to pass away in 2021.

BETTY WHITE, TELEVISION LEGEND, DEAD AT 99

The other cast members who died during the year were Cloris Leachman, who played Phyllis Lindstrom (Jan. 27); Gavin MacLeod, who played Murray Slaughter (May 29); and Ed Asner, who played Lou Grant (Aug. 29).

Mary Tyler Moore (as Mary Richards) sits at her desk, left, as Betty White (as Sue Ann Nivens) ,center, talks to her and Gavin MacLeod (as Murray Slaughter) seated right, in a scene from "The Mary Tyler Moore Show" in the mid-1970s. Behind them, to the right, are Ted Knight (1923 - 1986) (as Ted Baxter) and Georgia Engel (as Georgette Franklin Baxter). (Getty Images)

The show also saw two cast members die in 2019: Georgia Engel, who played Georgette Baxter (April 12) and Valerie Harper, who played Rhoda Morgenstern (Aug.30).

Series star Mary Tyler Moore, aka Mary Richards, died in 2017, while Ted Knight, aka Ted Baxter, died in 1986.

"Mary Tyler Moore Show" stars hold Emmy Awards for the 1975-76 season. From left: Edward Asner, Betty White, Mary Tyler Moore and Ted Knight. All won Emmys that year for "MTM," except Asner, who won his for a performance in "Rich Man, Poor Man." (Getty Images)

Ed Asner Cloris Leachman

Ed Asner and Cloris Leachman are seen in Beverly Hills, California, in an undated photo. (Getty Images)

The loss of the show’s top stars means that only a handful of actors who had limited roles on the series remain. They include John Amos (Gordy Howard), who took part in the show’s early years, then returned for an appearance in 1977; Joyce Bulifant, who occasionally appeared as Murray’s wife Marie; and Lisa Gerritsen, who played Phyllis’ daughter Bess.

John Amos, right, was already well-known for his role as Gordy Howard, the weatherman on "The Mary Tyler Moore Show," when he was cast for "Maude," and later "Good Times." 

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Several other actors also had brief repeated roles as relatives or romantic interests of the characters.

The show ran from 1970 to 1977.