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Health officials said there have been 221 new deaths, for a total of 2,182 fatalities according to The Associated Press.
It was reportedly the most deaths confirmed in a single day since the outbreak began in the state, and the first time the daily death rate was over 200.
"We're still seeing an increase, a modest one, but an increase statewide," Gov. Charlie Baker, a Republican, said. "We've seen this data bounce around before."
The state is now viewed as a hotspot with nearly 43,000 total cases, which is third in the United States, behind only New Jersey and New York. The state also ranked fourth in the number of fatalities nationwide.
As of Wednesday, the U.S. had nearly 847,000 confirmed cases of coronavirus and over 46,000 deaths.
Fox News' Vandana Rambaran, Kayla Rivas and The Associated Press contributed to this report