Two Honduran brothers who ran what prosecutors describe as one of the world's largest drug trafficking organizations are set to plead guilty to criminal charges in a U.S. court.

Court records indicate plea hearings are scheduled Thursday for 43-year-old Miguel Arnulfo Valle Valle and 46-year-old Luis Alonso Valle Valle. Authorities say the Los Valles cartel was responsible for distributing of tens of thousands of kilograms of cocaine every month into the U.S.

A third brother, Jose Valle Valle, pleaded guilty to related charges Tuesday in federal court in Alexandria. Court records indicate he played a lesser role in the conspiracy, but he still faces a mandatory minimum sentence of 10 years in prison.

Authorities say Honduras is a key transfer point for Colombian cocaine into Mexico and eventually the U.S.