Adam Warren will make his major league debut this evening when the New York Yankees continue a four-game set with the Chicago White Sox at Yankee Stadium.

With Andy Pettitte and CC Sabathia on the disabled list, the Yanks had intended on throwing veteran Freddy Garcia tonight. However, he threw out of the bullpen on Wednesday, opening the door for Warren, who becomes the first Yankees pitcher to make his major league debut as a starter since Ian Kennedy on Sept. 1, 2007.

"It's hard to put into words how excited I am," Warren told the Yankees' official website. "It's been a dream of mine for so long. Just to be here and be in the clubhouse right now, it's pretty neat. I'm just trying to soak it up and have fun."

Warren, 24, had been 5-5 with a 3.86 ERA in 15 starts for Triple-A Scranton/Wilkes Barre this season. He threw five scoreless innings his most recent time out.

Chicago, meanwhile, will counter with a young hurler of its own in 23-year-old lefty Jose Quintana, who has thrown 16 consecutive scoreless innings, the longest streak for a White Sox rookie pitcher since Brandon McCarthy went 17 1/3 innings.

Quintana, a former Yankees farmhand, did not get a decision despite a terrific showing on Sunday against Milwaukee that saw him scatter six hits in eight scoreless innings. He also gave up five hits in eight scoreless innings in his previous start also without earning a decision.

He is 2-1 on the year with a 1.25 ERA. This will be his first start against the Yankees.

"For me, it's always staying even keel," Quintana said. "I go out each game and try to do what I've done and staying consistent. Nothing changes. I know [Friday] will be a big start for me. But I'm going to go out like I've done every start.

Chicago won in dramatic fashion on Thursday, as Dayan Viciedo made the Yankees pay for a bad throw, hitting a three-run homer in the ninth inning to lift the White Sox to a 4-3 win in the opener of a four-game series.

"We got the one break and he jumped on it," remarked White Sox manager Robin Ventura about Viciedo's home run. "He's got power and he's shown it."

Viciedo's go-ahead blast off David Robertson (0-2) came after Yankees reliever Clay Rapada sailed a throw into center field on a tailor-made double play ball with no outs, leaving two men on base.

The Yankees put a runner on in the bottom of the ninth, but Derek Jeter lined out to the wall in deep right to end their five-game winning streak.

"We got the double play ball and made a bad play," said Yankees manager Joe Girardi. "That's a tough way to lose but it's a physical error and you just have to move on."

Alejandro De Aza also homered for the White Sox, who have won five of their last six.

Hector Santiago (2-1) got the win despite giving up a solo home run to Mark Teixeira in the eighth. Addison Reed pitched around Dewayne Wise's single to earn his 11th save.

"I really let the team down," said Rapada. "I was throwing to his chest and I didn't do it."

The Yankees have won six of seven from the White Sox and are 15-6 in their last 21 at home in the series.