CLEVELAND (AP) -- Tim Anderson homered on the game's first pitch, Matt Davidson added a three-run shot in a five-run first inning and the Chicago White Sox beat the slumping Cleveland Indians 10-4 on Thursday night.
The defending AL champions have lost five of six after sweeping Texas to begin the season and dropped to 4-5.
Anderson hit Josh Tomlin's first pitch onto the porch in left field while Davidson lined a two-out homer to right-center.
Cleveland used five pitchers in the first eight innings, forcing infielder Michael Martinez to work the ninth. Making his first career appearance on the mound, Martinez gave up a single but retired the other three hitters on grounders.
Avisail Garcia was 3 for 4 with three RBIs. Anthony Swarzak (1-0) relieved starter Miguel Gonzalez in the fifth and allowed one hit in 1 2/3 innings.
Tomlin (0-2) gave up seven runs in 1 2/3 innings, matching the shortest outing of his career.
Michael Brantley, who played in just 11 games last season because of two shoulder operations, homered in the fifth -- his first since Sept. 10, 2015.
Gonzalez was handed an early 7-1 lead, but couldn't go the required five innings for the win. He allowed three runs in 4 2/3 innings and was pulled after the Indians scored twice in the fifth.
Lonnie Chisenhall had an RBI single in the fifth for Cleveland, which has scored 35 runs in nine games.
Edwin Encarnacion, who signed a three-year, $60 million contract in January, was 0 for 3 with two walks, dropping his average to .156. Encarnacion hit a solo homer on opening day for his only RBI of the season.
Davidson was replacing Todd Frazier at third base for the second straight game. Frazier is battling the flu, but is expected to return this weekend.
Yan Gomes hit a solo homer in the eighth, snapping an 0-for-12 slump.
White Sox: C Geovany Soto (right elbow inflammation) was placed on the 10-day disabled list. C Kevan Smith was recalled from Triple-A Charlotte.
Indians: 2B Jason Kipnis has a bruised and swollen left hand after being hit by a pitch in a minor league game Wednesday. He could resume his rehab assignment Saturday. Kipnis is on the 10-day DL with a sore right shoulder.
White Sox: RHP Dylan Covey, a Rule 5 selection from Oakland, makes his major league debut in the opener of a three-game series at Minnesota.
Indians: RHP Trevor Bauer (0-1) will start the opener of a three-game series against Detroit. He allowed four runs in 5 2/3 innings on April 8 at Arizona.