Wallace, Sanders lead No. 14 Mississippi to 56-15 win over Louisiana-Lafayette

Louisiana-Lafayette running back Alonzo Harris (46) runs past a Mississippi defender for a first down during the first quarter at an NCAA college football game at Vaught-Hemingway Stadium in Oxford, Miss., Saturday, Sept. 13, 2014. (AP Photo/Rogelio V. Solis) (The Associated Press)

Mississippi running back I'Tavius Mathers (5) hurdles over Louisiana-Lafayette defenders on his way to a 56-yard touchdown run during the first quarter at an NCAA college football game at Vaught-Hemingway Stadium in Oxford, Miss., Saturday, Sept. 13, 2014. (AP Photo/Rogelio V. Solis) (The Associated Press)

OXFORD, Miss. – Bo Wallace threw for 316 yards and four touchdowns, including two to Vince Sanders, to lead No. 14 Mississippi over Louisiana-Lafayette 56-15 on Saturday.

Ole Miss (3-0) has never lost to Louisiana-Lafayette (1-2) and this one wasn't in doubt for very long. I'Tavius Mathers rushed for a 56-yard touchdown on the first drive and the Rebels pushed out to a 28-0 lead by midway through the second quarter.

Wallace completed 23 of 28 passes for an offense that gained 554 total yards. Sanders finished with a career-high eight receptions for 125 yards and touchdown catches of 14 and 24 yards.

Senquez Golson intercepted two passes, including one that was returned 59 yards for a touchdown.

Louisiana-Lafayette fell behind 49-6 by midway through the third quarter before scoring its only touchdown. Terrance Broadway completed 15 of 30 passes for 129 yards and three interceptions.