Wake Forest struggled to contain Clemson's speedy receivers, and the 14th-ranked Tigers piled up the points. The result was yet another lopsided loss to a Top 25 opponent.

The Demon Deacons had no answers for Tajh Boyd, Sammy Watkins or the rest of Clemson's big-play offense in a 42-13 loss Thursday night.

Wake Forest let Boyd throw for a school-record 428 yards with five touchdown passes, couldn't stop Watkins from setting a Clemson record with 202 yards receiving and were blown out by another nationally ranked Atlantic Coast Conference team.

The Demon Deacons have played two such opponents — No. 11 Florida State and Clemson — and have been outscored 94-13 while allowing 1,146 total yards.

"I don't know that we didn't respect" the Tigers' speed, coach Jim Grobe said. "I think we didn't realize how fast those guys were."

Tanner Price was 27 of 44 for 232 yards for Wake Forest. He threw a pair of touchdown passes to Tommy Bohanon, but was clearly outdueled by Boyd — who was 27 of 38 and connected with Watkins for three plays of 50 or more yards, including a 61-yarder for a score.

"Tajh was just lights out," coach Dabo Swinney said. "And now maybe everybody will quit asking me about Sammy Watkins."

Watkins, who missed three games because of suspension and illness, had eight receptions. Boyd added touchdown throws of 9 yards to Brandon Ford, 12 yards each to Sam Cooper and DeAndre Hopkins and 2 yards to Charone Peake.

The Tigers (7-1, 4-1) scored the first 35 points, including a four-touchdown second quarter, in their fourth consecutive victory and fourth straight in the series with the Demon Deacons (4-4, 2-4).

Five days after Virginia Tech held Clemson to season lows in every significant offensive statistic except the final score, the Tigers rolled up 534 total yards and essentially ended this one at halftime.

"We expect to execute in a manner that we score every time we get the ball," Boyd said. "So when you don't do it, sometimes it's kind of frustrating. Sometimes it's kind of disappointing. But all you can do is just keep working, keep pushing."

Boyd broke Charlie Whitehurst's 10-year-old record of 420 yards passing after Watkins took care of the school's receiving mark of 197 yards set last month by Hopkins against Boston College.

"We knew that was coming," offensive coordinator Chad Morris said of Watkins. "You see that spark, and it just gives everybody that much energy. ... Getting him going at the right time — this team's going to need him the most at this point in time in the season."

Morris said the coaches left Boyd in well into the fourth quarter because they wanted him to reach 400 yards passing for the first time — and wound up with the record when he hit Martavis Bryant for 37 yards.

D.J. Howard added a late 1-yard touchdown run for Clemson, which was legitimately concerned after its lackluster 38-17 victory over the Hokies. In that game, the Tigers managed just 160 yards passing, 135 yards rushing and 295 total yards — a performance that left Morris vowing it wouldn't happen again.

It certainly didn't — at least, not during an overwhelming first half.

The defending ACC champions eclipsed last week's yardage total by halftime, gaining 343 yards before the break.

Watkins, who sat out for the Tigers' first three plays because he was three minutes late for a team meeting, got the offense rolling on its third possession. He slipped behind the Wake Forest secondary and Boyd found him down the left sideline for the 57-yard pass that set up his touchdown pass to Ford.

Watkins then made it 14-0 on the first play of the second quarter when he took a throw from Boyd near the sideline, shook off two tacklers and outran two more on his way to his first touchdown reception of the season.

"You give up a big play or two, that kind of gets everybody a little bit spooky back there and then you give up a couple more by not playing real aggressively," Grobe said.

Boyd, who also threw for five TDs last year in a home win against North Carolina, then hit Cooper with a scoring pass 6 minutes later, and by then, the Tigers were well on their way to their sixth win in seven meetings with Wake Forest.