Fort Worth, TX – Waymon James ran for 108 yards, while 10.
With the win, TCU has clinched at least a share of the Mountain West title, but can win the crown outright for the third consecutive year with a win over UNLV on December 3.
Ed Wesley added 63 yards rushing and a score for the Horned Frogs (9-2, 6-0 MWC), who totaled 255 yards on the ground.
Casey Pachall was 13-of-20 passing for 117 yards and Tank Carder had a 69- yard interception return for a touchdown in the win.
Garrett Grayson completed 14-of-24 passes for 248 yards, with a touchdown and interception for Colorado State (3-7, 1-4), which lost its sixth straight game.