LAWRENCE, Kan. (AP) -- Baker Mayfield completed 27 of 32 passes for 383 yards and four touchdowns and No. 14 Oklahoma beat Kansas 62-7 on Saturday.
Sterling Shepard had 183 receiving yards and a touchdown on 11 catches. Samaje Perine added 90 rushing yards and two touchdowns on 11 carries for the Sooners (7-1, 4-1 Big 12).
Oklahoma coach Bob Stoops is now 11-0 against the Jayhawks in his career. Kansas (0-8, 0-5) has dropped 11 consecutive games dating back to last season.
The Sooners led 38-7 at halftime.
Oklahoma scored on its first drive of the second half when Sam Grant snagged a 1-yard touchdown pass from Mayfield. Kansas fumbled on the first play of the next drive, and Oklahoma quickly took a 52-7 lead after backup quarterback Trevor Knight finished a short drive with a 1-yard touchdown run.
The Sooners kicked a field goal with 2:03 remaining in the third quarter, upping their lead to 55-7. Oklahoma pushed its advantage to 62-7 when Knight connected with his twin brother, Connor Knight, for a 17-yard score with 5:32 left in the game.
The Jayhawks had no answer for a powerful Sooners offense that scored 50 points for the third time in as many games. It was the first time Oklahoma has done that since 2008, when quarterback Sam Bradford won the Heisman Trophy.
Oklahoma took a 7-0 lead early in the first quarter when Mayfield threw a strike to Joe Mixon, who outran defenders for a 68-yard touchdown. The Sooners scored again on their next drive, which culminated in an 11-yard touchdown pass to Durron Neal. On the following drive, Shepard's leaping catch in the end zone stretched Oklahoma's lead to 21-0 with 1:51 left in the first quarter.
Oklahoma outgained Kansas 248-41 in the first 15 minutes of play.
The Jayhawks showed signs of life in the second quarter after recovering Shepard's muffed punt. Kansas took advantage of the short field, and Ryan Willis found Tyler Patrick for a 17-yard touchdown that brought Kansas within 21-7.
With 9 minutes remaining in the half, Oklahoma upped its lead to 28-7 with a 3-yard rushing touchdown by Perine. The score capped a 14-play drive that lasted nearly 6 minutes. Mayfield was sacked twice during the drive and the Sooners hurt themselves with a 15-yard penalty, but Oklahoma still found the end zone.
On its next drive, Kansas threw a wrinkle at the Sooners when it had Willis punt, and the ball rolled out of bounds at the 3-yard line. The Sooners settled for a 46-yard field goal on the ensuing drive, taking a 31-7 lead.
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