By Simon Evans
Roddick was especially delighted to win the crown after losing the Indian Wells final to Croatian Ivan Ljubicic two weeks ago.
"I think just the last month has been real good for me."
There was nothing to choose between the pair for most of a high quality first set, with Berdych producing some delightful lobs and Roddick unleashing his powerful serve.
But Roddick, who went to high school in South Florida and played many of his early junior tournaments on the Crandon Park courts, broke in the 11th game and then served out the set in style, finishing with a magnificent ace.
The 27-year-old American, who had last won a Masters event in 2006, then grabbed the momentum when he broke Berdych's first serve of the second set with some blistering forehand strokes.
But he faced tenacious opposition throughout from Berdych who had beaten world number one Roger Federer on his way to the final.
There was much more to Roddick's game than his trademark blasting serve, he sliced well and was smart on his feet.
"He was really good today. He was really strong, serving well I was looking to get one chance or maybe one is enough," said Berdych.
"But he held pretty well. I didn't get a chance during the whole match."
"I've played well on the big moments. Haven't had an off day mentally. I've been able to execute. I've been able to have a game plan and execute it regardless of what kind of shots it takes. So it's all good." said the world number eight.
(Editing by Sonia Oxley and Pritha Sarkar)