ST. PETERSBURG, Fla. (AP) -- Brian McCann and Yuli Gurriel both had RBI singles in the 10th inning, and the Houston Astros rallied from an early four-run deficit to beat the Tampa Bay Rays 6-4 on Sunday.
Carlos Beltran opened the 10th by drawing a walk from Ryan Garton (0-1) and went to second on Jose Altuve's single. After reaching third on Carlos Correa's fly to center, Beltran scored to make it 5-4 on McCann's hit to right.
Gurriel's two-out single put Houston ahead 6-4.
Luke Gregerson (1-1) went a scorless ninth before Ken Giles got three out for his fifth save.
The Astros tied it at 4 on pinch-hitter Evan Gattis' sacrifice fly off closer Alex Colome, who was bidding for a two-inning save, in the ninth.
Brad Miller had an RBI triple, Steven Souza Jr. hit a two-run homer, and Jesus Sucre added a run-scoring single as the Rays went up 4-0 in the first.
After Correa had two-run shot during the third, Altuve got Houston within 4-3 on a solo homer in the fifth.
Joe Musgrove gave up four runs and five hits -- all in the first -- over six innings for the Astros. He allowed just two baserunners -- on catcher's interference and a walk -- from two outs in the first through the sixth.
Three Houston relievers held the Rays to two hits.
Tampa Bay's Matt Andriese allowed three runs and six hits in five innings.
Astros center field Jake Marisnick was replaced defensively to start the bottom of the third due to concussion-like symptoms. He had remained in the game after running face first into the center-field fence while catching Logan Morrison's first-inning drive.
Astros: OF George Springer had his major-league leading streak of playing in 205 consecutive games end because of left hamstring discomfort. He was hurt running out a grounder Saturday and is day to day. "It's a bummer for him, and I was proud of him because at the beginning of his career he had to answer so many questions about his injuries," manager A.J. Hinch said. "And then last season he played in every game."
Rays: CF Kevin Kiermaier, who left both Friday and Saturday's games due to illness, entered as a defensive replacement in the eighth. … RHP Tommy Hunter (right calf strain) was placed on the 10-day disabled list and RHP Chih-Wei Hu was recalled from Triple-A Durham.
Astros: LHP Dallas Keuchel (3-0) takes the hill Tuesday night against Cleveland RHP Josh Tomlin (1-2). Keuchel has opened the season with four straight starts of seven innings, while allowing one or fewer runs in each outing. Only one other Astros pitcher, RHP Roger Clemens in 2005, has done it.
Rays: RHP Chris Archer (2-0) will face Baltimore RHP Ubaldo Jimenez (1-0) Monday night as Tampa Bay starts a three-city, eight-game road trip. The Rays are 1-6 on the road, compared to 9-4 at home.