Juventus had two men sent off as their dismal start to the Serie A season continued at Roma.
The champions, who lost their opening match at home to Udinese last week, went down 2-1 at the Stadio Olimpico and had Rubinho and Patrice Evra sent off in the final quarter.
Miralem Pjanic opened the scoring for Roma with an impressive free-kick just past the hour mark and, after their opponents had been reduced to nine men, Edin Dzeko headed home with 11 minutes remaining to double the advantage.
Paulo Dybala pulled a goal back in the 88th minute and the visitors launched a belated battle for an unlikely point. However, it did not come and Juve, who won the league by 17 points last season, find themselves without a point from their first two games of this campaign.