Jordy Nelson racked up 123 yards and a pair of scores on just six receptions, and Tom Crabtree added a TD catch for the Packers (10-0), who matched the 1962 squad for the best start in franchise history.
James Starks collected 53 yards on six grabs and 38 yards on 11 carries, with B.J. Raji and John Kuhn posting a rushing score each as Green Bay extended its winning streak to 16 games dating back last year's Super Bowl run.
Kellen Winslow totaled a game-highs of 132 receiving yards and nine catches for the Buccaneers (4-6), who have dropped four straight games. Josh Freeman completed 28-of-38 passes for 342 yards and two touchdowns but was picked off twice by Tramon Williams.