Clemson, SC – Tajh Boyd threw a career-high five touchdown 38.
Boyd was 27-of-46 for 367 yards for the Tigers (8-0, 5-0 ACC), who matched their best start since 2000.
DeAndre Hopkins also set a career-high with 157 yards and a score on nine catches, and Sammy Watkins continued his stellar freshman campaign with 91 yards and a touchdown.
Clemson defensive end Kourtnei Brown had two defensive touchdowns, the first defensive lineman in school history to do so since Walt Larraway against Citadel in 1954.
North Carolina (5-3, 1-3) hung in the game early, but six turnovers led to its demise.
Bryn Renner, who hadn't thrown an interception in his last three games, threw three picks and lost one fumble. He threw for 264 yards and two touchdowns on 19-of-33 passing.
Jheranie Boyd caught three balls for 95 yards and two scores.
