Naples, Italy – Napoli will attempt to end a poor run of form leaders Juventus in a battle five teams.
Juve enters the match one point clear at the top of the table and is the only unbeaten side left in the league, while Napoli has recorded just one win in its last six games in all competitions.
The poor run of form has dropped the club down to fifth in the league and into third place in its Champions League group after a 3-2 defeat at Bayern Munich in midweek.
The defeat to Bayern came following a 2-1 loss to Catania, while Juve has won its last two games to take over the lead in the league.
Inter Milan visits Genoa on Sunday after another Champions League success for the Nerazzurri, which has won its last three games in the competition.
Claudio Ranieri's team has moved four points clear in Group B after a 2-1 triumph over Lille, but Inter's form in the league must improve dramatically with the club having won just two of its first nine games in Serie A.
AC Milan has won four straight games in the league and goes for another three points at home against Catania on Sunday, while Udinese sits one point off the pace at the top of the table and entertains Siena.
Lazio is level with Udinese on 18 points and hosts Parma, Atalanta has won once in its last five games and takes on Cagliari, while Cesena searches for its first win of the season when the club hosts second-from-the-bottom Lecce.
The two matches on Saturday feature Bologna searching for a third straight win against a Palermo side that has lost three of four, while Novara attempts to halt a six-game winless streak when the club hosts Roma.