The MLB stars faced Chien-Ming Wang, who signed with the Washington Nationals this past week and started for Chinese Taipei. Wang was held to a pitch count and reached it in the third inning before being removed.
Sunday's game was a back-and-forth contest that featured early runs. MLB had a 3-0 lead after the second inning, when Angels catcher Jeff Mathis singled in a run and teammate Erick Aybar followed with an RBI double.
Chinese Taipei evened the score, but the solo blast by the Yankees' Cano -- which came just after Wang left the game -- put MLB back on top.
The Chinese Taipei team evened the game again, but an RBI double by Marlins outfielder Logan Morrison and a solo homer by the Rockies' Wigginton gave the MLB stars enough runs to win.
Baltimore's Jeremy Guthrie started for MLB and allowed three runs in four innings.
MLB won the opener of the series, 7-0, behind a grand slam by Curtis Granderson. After taking a 5-3 victory on Thursday, Washington's Michael Morse doubled in a run and added a solo homer in a 6-2 win on Friday. MLB earned a 3-2 win on Saturday.