Over the season's first two months, nothing had rattled unbeaten Indiana.

Until it ran into Michigan State's pressure defense and the imposing presence of the Breslin Center.

Keith Appling scored a career-best 25 points and Derrick Nix chipped in with 12 off the bench, as 16th-ranked Michigan State held Indiana scoreless for six-plus minutes down the stretch in an 80-65 victory over the 13th-ranked Hoosiers.

Brandon Wood scored 13 points and Draymond Green donated 11 points, seven rebounds and four assists for the Spartans (12-2, 1-0 Big Ten), who have won 12 straight and haven't lost since a November 15th setback to Duke.

Christian Watford led Indiana (12-1, 0-1) with 26 points and Verdel Jones III posted 11. The Hoosiers must rebound quickly for their conference home opener on Saturday versus second-ranked Ohio State.