Updated

Over the season's first two months, nothing had rattled unbeaten Indiana.

Until it ran into Michigan State's pressure defense and the imposing presence of the Breslin Center.

Keith Appling scored a career-best 25 points and Derrick Nix chipped in with 12 off the bench, as 16th-ranked Michigan State held Indiana scoreless for six-plus minutes down the stretch in an 80-65 victory over the 13th-ranked Hoosiers.

Brandon Wood scored 13 points and Draymond Green donated 11 points, seven rebounds and four assists for the Spartans (12-2, 1-0 Big Ten), who have won 12 straight and haven't lost since a November 15th setback to Duke.

Christian Watford led Indiana (12-1, 0-1) with 26 points and Verdel Jones III posted 11. The Hoosiers must rebound quickly for their conference home opener on Saturday versus second-ranked Ohio State.