Baker Mayfield passed for a season-high 247 yards and two touchdowns against the NFL's No. 1 defense, Myles Garrett forced a crucial safety in the fourth quarter and the Cleveland Browns held on for a 32-23 win over the Indianapolis Colts on Sunday.

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Cleveland improved to 4-1 for the first time since 1994.

Mayfield made sure the Browns (4-1) kept the momentum going in their first game without Pro Bowl running back Nick Chubb, who sprained his knee last week. Mayfield, though, appeared to hurt his right hand in the fourth quarter.

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Cheered on by 12,000 fans inside FirstEnergy Stadium, Mayfield threw TD passes to Kareem Hunt and Rashard Higgins in the first half while rolling up 228 yards passing. The Colts' defense came in allowing the fewest passing yards, points and led the NFL in interceptions.

The Browns seemed to be in total control when safety Ronnie Harrison picked off Philip Rivers and returned it 47 yards for a TD in the third quarter to give Cleveland a 27-10 lead.

But Colts returner Isaiah Rodgers brought back the ensuing kickoff 101 yards for a TD — the longest play in the league this season. Then the Browns turned to their defense and a huge run by backup running back D'Ernest Johnson to finish the job.

With Cleveland clinging to a 27-20 lead, Garrett pressured Rivers into an intentional grounding call from the end zone for a safety.

On the Colts' next possession, Browns safety Sheldrick Redwine, who came in while Harrison was being evaluated for a concussion, picked off Rivers.

Indianapolis (3-2) closed within 29-23 on Rodrigo Blankenship's 25-yard field goal with 2:50 left. But Cleveland ran out the clock with Johnson picking up 28 yards on a third-and-9 play before Cody Parkey's 46-yard field goal with 21 seconds left sealed it.

It was a rough performance for the 38-year-old Rivers, who completed 21 of 33 passes for 243 yards and the two picks.

Mayfield's 15-yard TD pass to a wide-open Higgins gave the Browns a 17-10 lead in the second quarter. It was the first scoring connection between the pair this season. Higgins, who had been a favorite target of Mayfield's in 2018, didn't play much last season, had been a healthy scratch for two games in 2020, and dropped on the depth chart.

But after his score, Higgins broke out his red-carpet walk celebration as his teammates pretended to take his photograph.

Mayfield showed patience on his 2-yard scoring pass to Hunt, which gave the Browns a 10-7 lead early in the second quarter.

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RIVERS ROLLS ON

Rivers did make some history. He started his 229th consecutive game, tying him with Hall of Fame lineman Bruce Matthews for the second-longest in league history. Brett Favre started 297 games in a row.

Rivers also became the fifth quarterback with 5,000 career completions, joining Favre, Drew Brees, Tom Brady and Peyton Manning.

INJURIES

Colts: DT Denico Autry left in the first half with an ankle injury. ... Safety Julian Blackmon left with a groin injury.

Browns: Starting RG Wyatt Teller left with a calf injury in the first quarter and didn't return. Chris Hubbard took his spot. ... Rookie LB Jacob Phillips injured his knee in the second half. ... DE Olivier Vernon left with a groin injury in the fourth period.

UP NEXT

Colts: host Cincinnati on Oct. 18 before their bye week.

Browns: visit rival Pittsburgh on Oct. 18. The Steelers are 4-0 for the first time since 1979.