Leverkusen, Germany – Bayer Leverkusen will be without 2 draw with Stuttgart on Saturday.
Sam had recently returned to the lineup after recovering from another muscle injury, but after entering the match in the 72nd minute, he had to come off 12 minutes later.
The 24-year-old underwent tests after the match and manager Robin Dutt confirmed the extent of the injury.
"It's obviously a difficult situation for us at the moment, as almost every week we have new injuries to complain about. Sidney Sam will definitely be unavailable for the next two months," Dutt told reporters after the game.
Sam has scored four goals in 18 Bundesliga appearances this season for Leverkusen, which sits in sixth place in the league table.