CLEVELAND (AP) -- Edwin Encarnacion homered and matched a career high with four hits, All-Star Jose Ramirez hit a home run and had three RBIs, and the Cleveland Indians, playing their third straight game without manager Terry Francona, defeated the San Diego Padres 11-2 on Thursday night.
Francona remained hospitalized at the Cleveland Clinic, where he has been undergoing tests to resolve the causes of him becoming light-headed over the past month. The 58-year-old was hospitalized twice last month and doctors admitted him Tuesday, about one week after he began wearing a heart monitor.
Bench coach Brad Mills filled in again for Francona.
Josh Tomlin (5-9) allowed two runs in seven-plus innings. The right-hander retired the first 12 hitters before San Diego scored twice in the fifth.
Encarnacion was 4 for 5, including a leadoff homer in the fifth and an RBI double in the sixth. He also singled in the third and eighth.
Ramirez, who will start at third base for the American League in the All-Star Game, hit a two-run homer in the first, had an RBI single in the sixth and was 3 for 5.
Lonnie Chisenhall drove in three runs and Yan Gomes also homered. All-Star Michael Brantley had an RBI triple in the first for Cleveland, which was held to two runs in dropping the first two games of the series.
Ramirez's homer, his 16th of the season, capped a three-run first. Encarnacion led off the fifth with a blast to dead-center, his team-high 18th.
Dinelson Lamet (3-3) was removed after Encarnacion's home run. The rookie right-hander allowed six runs -- five earned -- in four-plus innings.
Tomlin allowed four hits, struck out six and didn't walk a batter.
Hunter Renfroe started the fifth with a double to left-center and moved to third on Cory Spangenberg's single. Aybar's ground rule double scored a run and Cordoba's sacrifice fly made it 5-2.
Padres: C Austin Hedges (stiff neck) was out of the lineup for the second straight day, but is expected to start Friday against Philadelphia.
Indians: RHP Danny Salazar (sore shoulder) allowed three solo homers in 3 1/3 innings during a rehab start for Triple-A Columbus. He was pulled after 60 pitches.
Padres: LHP Clayton Richard begins a three-game series at Philadelphia. He leads the National League with 196 ground balls induced, but has just five victories in 17 starts.
Indians: RHP Carlos Carrasco opens a three-game home series against Detroit. He earned his team-high ninth win by going seven innings against the Tigers on July 1.