Campbell picked up the first time but with 8:23 left in the first quarter, he was in clear pain. He was holding his left knee after the play was over.
He was carted off the field with an injury.
The 23-year-old wide receiver is in his second season with the Colts. He played last week against the Jacksonville Jaguars and caught six passes for 71 yards on nine targets.
In his 2019 rookie season, he had 18 catches for 127 yards and a touchdown in seven games.
Indianapolis selected Campbell in the second round of the 2019 draft out of Ohio State. He played for the Buckeyes from 2014 to 2018. He was redshirted his freshman year.
He was a two-time Big Ten champion and earned First Team All-Big Ten honors in 2018.
He was hoping to help the Colts to their first win before Sunday’s injury.