The Republican governor's move comes even as he acknowledged that the pandemic was far from over.
“We’re not closing anything going forward,” he told reporters, insisting that the state is prepared if infections climb once again.
According to data from the Florida Department of Health, nearly 14,000 Floridians have already died.
On Friday, officials announced 2,847 new confirmed coronavirus cases and 120 new fatalities, according to the Associated Press.
The Sunshine State's caseload increased over the summer, but new infections have declined since then.
The initial outbreak forced DeSantis to shutter bars and nightclubs, and restricted restaurants to take-out dining.
Nationwide, the virus battered the American economy — leaving hundreds of thousands of Floridians out of a job.
Businesses have slowly reopened, and restaurants and bars are now functioning at half capacity.
The governor also said he would stop cities and counties from collecting fines on people who don’t wear face masks.
The Friday announcement will allow restaurants to immediately reopen at full capacity and would block cities and counties from ordering restaurants to close unless they can justify a closure for economic or health reasons.
This is a developing story; check back for updates.