Jeanne Tripplehorn Says Jennifer Aniston 'Totally Comfortable' Directing Breast Cancer Film

It turns out Jennifer Aniston, after years in front of the camera, is also pretty comfy behind it.

"What is great about Jen is that she’s consistent, she brought that same energy and sparkle, and that love of life that she brings to everything. She was really at home and really comfortable not being in front of the camera, I really envy her for that," actress Jeanne Tripplehorn, who stars in Aniston's forthcoming short film "Five," told FOX411's Pop Tarts column the Variety Power of Women event. "She was very specific, and nurturing and gentle. All the qualities we love about her, she had as a director."

What's even better is that Aniston's directorial effort is all for a good cause, and guaranteed to bring tears to your eyes.

"'Five' is five short films, all dealing with a different character faced with the diagnosis of breast cancer. They face it with strength and dignity and a lot of humor," Tripplehorn continued. "We had five amazing women who came together, Jen directed as well as Demi Moore, Alicia Keys, Penelope Spheeris and Patty Jenkins."

Tripplehorn's role as an oncologist serves as the common thread which weaves all the tales together, as she bears the burden of delivering the devastating news to her patients, which include the likes of Patricia Clarkson and Rosario Dawson.

"Five" will air on Lifetime during Breast Cancer Awareness Month in October. Check your local listings for times.