Romania's health minister has resigned amid public outrage over the use of sub-standard disinfectants in dozens of Romanian hospitals.

Health Minister Patriciu Achimas-Cadariu resigned Monday, after authorities announced a probe into how the disinfectant was used at 50 hospitals.

Authorities on Saturday conducted searches at hospitals and the offices of drug company Hexi Pharma, which reportedly supplied dozens of hospitals with the disinfectant for use on surfaces and hands.

Police took away documents and samples from 25 hospitals, where tests revealed there were problems with the disinfectant.

About 500 people protested Friday in Bucharest over the latest scandal to hit the underfunded health care system. Thousands of medics emigrate annually and bribery and informal payments are rife in the system.