At least one American was among the 413 people confirmed dead from Ecuador's strongest earthquake in decades, the State Department reported Monday, as crews raced to save anybody who still might be alive and trapped underneath the rubble.
U.S. officials did not name the American who died.
The 7.8-magnitude quake left a trail of ruin along the normally calm Pacific coast, buckling highways, knocking down an air traffic control tower and flattening homes and buildings. Thousands of people are homeless.
"For God's sake help me find my family," pleaded Manuel Quijije, 27, standing next to a wrecked building in hard-hit Portoviejo. He said his older brother, Junior, was trapped under a pile of twisted steel and concrete with two relatives.
"We managed to see his arms and legs. They're his, they're buried, but the police kicked us out because they say there's a risk the rest of the building will collapse," Quijije said angrily as he looked on the ruins cordoned off by police. "We're not afraid. We're desperate. We want to pull out our family."
A grief-stricken aunt, Johana Estupinan, said her family was getting together to celebrate 17-year-old Sayira Quinde going off to college when a building collapse killed the teen, her mother, father and toddler brother. Now, Estupinan is traveling in a hearse to the town of Esmeraldas, where she will bury her loved ones and break the news of the loss to her sister's three now-orphaned children.
Also among the dead was Sister Clare Theresa Crockett, a 33-year-old Irish nun who worked at a school in in rural Playa Prieta, Sky News reported.
It is believed that Crockett was trying to help girls out of the school after the quake struck. Her body was found in the rubble of a collapsed staircase.
"She was the last sister found," her cousin Emmet Doyle told Sky News. "She was trying to get them down the stairs and the staircase collapsed. She died as she lived, helping others."
President Rafael Correa said early Monday that the death toll would "surely rise, and in a considerable way."
"The Ecuadorean spirit knows how to move forward, and will know how to overcome these very difficult moments," Correa said.
Ecuadorian Security Minister Cesar Navas told the Teleamazonas TV channel Monday morning that the death toll had risen to 350 from 272.
Portoviejo, a provincial capital of nearly 300,000, was among the hardest hit, with the town's mayor reporting at least 100 deaths. The Quinde family drove there from their home hours up the coast to drop off Sayira at Estupinan's house a week before she was to start classes at a public university on a scholarship to study medicine.
"She was my favorite niece," Estupinan said, emotionally torn apart after waiting at the city's morgue for hours. "I thought I was getting a daughter for the six years it was going to take her to earn a degree."
"I never thought my life would be destroyed in a minute," she added.
Estupinan watched as her loved ones were loaded onto a truck-sized hearse for the nighttime drive, the three older ones in dark mahogany coffins and 8-month-old Matias in a casket painted white. "It was supposed to be a short moment of family happiness but it converted into a tragedy," she said.
She hoped to bury her relatives in Esmeraldas on Monday, but devastation there is also severe and she worried about whether the hearse could make it along roads ripped apart by the quake.
The Saturday night quake knocked out power in many parts along the coast and some who fled to higher ground fearing a tsunami had no home to return to, or feared structures still standing might collapse. The country's Geophysics Institute said it recorded 230 aftershocks, some strong, as of Sunday night.
With makeshift shelters in short supply, many hunkered down to spend a second straight night outdoors huddled among neighbors.
Correa cut short a trip to the Vatican and flew directly to the city of Manta to oversee relief efforts. Even before touching Ecuadorean soil he signed a decree declaring a national emergency. Speaking from Portoviejo late Sunday he said the earthquake was the worst natural disaster to hit Ecuador since a 1949 earthquake in the Andean city of Ambato, which took over 5,000 lives.
"Our grief is very large, the tragedy is very large, but we'll find the way to move forward," Correa said. "If our pain is immense, still larger is the spirit of our people."
As rescuers scrambled through the ruins near the epicenter, in some cases digging with their hands to look for survivors, humanitarian aid began trickling in. More than 3,000 packages of food and nearly 8,000 sleeping kits were being delivered Sunday. Correa's ally, Venezuela, and neighboring Colombia, where the quake was also felt, organized airlifts. Mexico and Chile sent teams of rescuers.
Spain's Red Cross said as many as 5,000 people may need temporary housing after the quake flattened homes, and 100,000 may need some sort of aid.
On social media, Ecuadoreans celebrated a video of a baby girl being pulled from beneath a collapsed home in Manta.
But fear was also spreading of another night of looting after 180 prisoners from a jail near Portoviejo escaped amid the tumult. Authorities said some 20 inmates were recaptured and some others returned voluntarily.
Seeking security from any unrest, about 400 residents of Portoviejo gathered Sunday night on the tarmac of the city's former airport, where authorities handed out water, mattresses and food. The airport was closed in 2011 and flights diverted to a larger facility in nearby Manta after Correa kicked out a U.S. drug interdiction operation stationed there.
Shantytowns and cheaply constructed brick and concrete homes were reduced to rubble along the quake's path. In the coastal town of Chamanga, authorities estimated than 90 percent of homes had damage, while in Guayaquil a shopping center's roof fell in and a collapsed highway overpass crushed a car, killing the driver.
The government said it would draw on $600 million in emergency funding from multilateral banks to rebuild.
But in the meantime, the digging and hoping against the odds continued.
In downtown Portoviejo, a few blocks from where a four-story hotel fell onto the Quinde family's car, the six-story social security building was a pile of debris. Downed power cables were strewn across the street.
"The situation is heart-rending," Jaime Ugalde, editor of El Diario, the city's most-important newspaper, said as he surveyed the damage. "I'm going to return home and hug my wife and two kids. We're the lucky ones. We're alive."
The Associated Press contributed to this report.