The son of notorious Mexican drug cartel leader Joaquin "El Chapo" Guzmán was nabbed Thursday after a six-month interagency investigation, Mexican authorities confirmed. 

During an afternoon press conference, Defense Secretary Luis Cresencio Sandoval said Guzmán’s son – whom he only identified as "Ovidio" – was arrested early Thursday morning northwest of Culiacan in the state of Sinaloa

Ovidio Guzman Lopez

FILE - This Oct. 17, 2019 frame grab from video provided by the Mexican government shows Ovidio Guzman Lopez at the moment of his detention, in Culiacan, Mexico. Mexican security forces were forced to release the son of Sinaloa cartel leader Joaquin "El Chapo" Guzman that day after his gunmen shot up the western city of Culiacan.  (CEPROPIE via AP File)

Sandoval said Guzmán was a leader of a Sinaloa faction he called "los menores" or "the juniors," who are also known as "Los Chapitos," for the sons of El Chapo. 

Guzmán’s arrest was the result of six months of interagency investigation and surveillance work, Sandoval said. 

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National Guard troops spotted SUVs, some with homemade armor, and immediately coordinated with the army as they established a perimeter around the suspicious vehicles and forced the occupants out to be searched.

The security forces then came under fire but were able to gain control of the situation and identify Guzmán among those present and in possession of firearms, Sandoval said.

Ovidio Guzmán-López

Ovidio Guzmán-López, son of drug kingpin El Chapo.  (US State Department)

Cartel members set up 19 roadblocks including at Culiacan's airport and outside the local army base, as well as all points of access to the city of Culiacan, Sandoval said, but the Air Force was able to fly Guzmán to Mexico City despite their efforts, and he was taken to offices of the Attorney General's organized crime special prosecutor.

Ovidio Guzmán, nicknamed "the Mouse," had not been one of El Chapo's better-known sons until an aborted operation to capture him three years ago. That attempt similarly set off violence in Culiacan that ultimately led President Andrés Manuel López Obrador to order the military to let him go.

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U.S. Homeland Security Investigations had posted a $5 million reward for information leading to the arrest and/or conviction of Guzmán last year. 

Alleged cartel members responded to Thursday’s operation by carjacking Culiacan residents and setting vehicles ablaze in the cartel stronghold. Local and state authorities warned everyone to stay inside.

El Chapo

Authorities escort Mexican drug lord Joaquin "El Chapo" Guzman, center, from a plane in Ronkonkoma, N.Y.   (U.S. law enforcement via AP)

Intermittent gunfire continued into the afternoon Thursday in Culiacan as Mexican security forces continued to clash with cartel gunmen and few people ventured out. Airports there and in several other Sinaloa cities remained closed.

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Thursday's high-profile capture comes just days before López Obrador will host U.S. President Joe Biden for bilateral talks followed by their North American Leaders' Summit with Canadian Prime Minister Justin Trudeau. Drug trafficking, along with immigration, is expected to be a top talking point.

The Associated Press contributed to this report.