A house exploded in a rural area of eastern Missouri on Friday, killing two children, authorities said.

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Emergency responders were called just before 7:45 a.m. to a home in Defiance, about 40 miles west of St. Louis. Two children were trapped in the house, but the intense flames prevented responders from getting to them.

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Two children were killed Friday in a Defiance, Missouri, home explosion. (Fox News Digital)

Two adults who lived in the home survived, authorities said. One suffered a minor injury and was treated at the scene. The other wasn't hurt.

A St. Charles County police officer also was treated for a minor injury.

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The cause of the explosion is under investigation and authorities haven't released the children's names.