Updated

A 26-year-old southeastern Indiana woman hospitalized with swine flu has died three weeks after her younger brother died of the disease.

Mindy McIntosh of Dillsboro, Ind., died Monday at University Hospital in Cincinnati.

Family friend Mike Dittmer says McIntosh had been improving before a blood clot in her lungs and a rapid change in blood pressure led to brain swelling.

Her 19-year-old brother Matthew McIntosh died July 5 from the virus at University Hospital. The siblings lived with their mother about 30 miles west of Cincinnati and were hospitalized after falling ill in late June.

Their mother has said neither of them traveled out of the country and she didn't know how they caught the virus.