The 33rd annual special will air live from the Shrine Auditorium in Los Angeles Nov. 22 on ABC (8 p.m. EST). Cedric the Entertainer will host the show.
Lohan will perform the single "Confessions of a Broken Heart (Daughter to Father)" from her upcoming album, "A Little More Personal (Raw)," ABC said Tuesday.
Previously announced performers include Mariah Carey, the Rolling Stones, Kenny Chesney, Tim McGraw and Keith Urban.
The American Music Awards honor the past year's elite in contemporary music as voted by record-buyers. Awards will be presented to top artists in pop/rock, country, soul/R&B, rap/hip-hop, Latin, alternative, contemporary inspirational and adult contemporary music.