The American Cancer Society is calling on millions of Americans to go cold turkey for the day.
It's the 28th annual Great American Smokeout, a day which many hope will be the first of many cigarette-free days.
The American Cancer Society says last year more than 8.3 million smokers participated in the Smokeout. That's about 20 percent of all the people who smoke in the country.
Statistics show about 70 percent of smokers want to quit and 35 percent try to each year. However, less than five percent succeed.
The American Cancer Society says each year 440,000 people die in the U-S from tobacco use.