Vance Worley struck out a career-high 11 in seven innings and combined with two relievers on a four-hitter as the Philadelphia Phillies beat the San Diego Padres 2-0 on Thursday night.

The Phillies have beaten the Padres 12 straight times at Petco Park dating to 2008. Overall, the Phillies are 23-4 at the ballpark since it opened in 2004. Dating back to Qualcomm Stadium, the Phillies have won 25 of 29 in San Diego.

Worley (1-1) held San Diego to four hits while walking three. His previous strikeout high was nine against the New York Mets on Aug. 23.

Jonathan Papelbon pitched the ninth for his fourth save.

The Padres struck out 12 times.

San Diego's Joe Wieland (0-2), making his second big league start, threw 31 pitches in the first inning, when he allowed one run before getting himself into and then out of a bases-loaded jam. Wieland walked leadoff batter Juan Pierre, who advanced to third on Placido Polanco's single and an error on left fielder Will Venable, then scored on Jimmy Rollins' sacrifice fly.

Wieland then allowed consecutive singles to Hunter Pence and Shane Victorino to load the bases before retiring John Mayberry and Carlos Ruiz.

San Diego wasted a chance to tie the game in the second when Jeremy Hermida hit a leadoff triple to right-center and was stranded.

The Padres had runners on the corners with one out in the sixth but failed to score. Hermida struck out and Venable was thrown out at home on a double-steal attempt. Venable collided with Ruiz, who held onto the ball.

Philadelphia added a run in the ninth on a passed ball.

NOTES: San Diego hasn't beaten Philadelphia at Petco Park since Aug. 16, 2008. ... Padres RHP Dustin Moseley, on the disabled list with extensive damage in his shoulder, says he'll have surgery but hasn't decided which doctor will perform it. ... The four-game series continues Friday night when Philadelphia's Cole Hamels (1-1, 3.65 ERA), who is from San Diego, is scheduled to start against San Diego's Edinson Volquez (0-1, 4.24).