Neither player has suited up since a Week 10 loss to the Cardinals.
Vick suffered two broken ribs in the 21-17 setback, while Maclin has been out with shoulder and hamstring injuries.
With Vick unable to go, the Eagles (4-7) will again turn to backup Vince Young, who threw for 400 yards in last Sunday's 38-20 shellacking at the hands of the Patriots.
Cornerback Dominique Rodgers-Cromartie (ankle), tackle King Dunlap (concussion) and linebacker Moise Fokou (ankle) have also been ruled out.
Vick also missed three games last season with a rib injury.