Jim Thome finished 3-for-4 with a pair of home - including his 600th career blast -- and drove in five as Minnesota 6, in the opener of a three-game series from Comerica Park.

The historic blast came in the seventh inning off Tigers left-handed reliever Daniel Schlereth. The 40-year-old became the eighth player in baseball history to reach the milestone, and the first since Yankees third baseman Alex Rodriguez last season.

Thome entered play with 598 career homers, and hit his first of the contest -- a two-run blast to left -- in the sixth inning off Detroit starter Rick Porcello.

Ben Revere added two hits and two RBI for the Twins, who won for just the second time in their last 10 games.

Francisco Liriano (8-9) gave up nine hits and five runs over six innings to earn the win. Joe Nathan shut the door in the ninth for his 10th save.