But wide-receiver Braylon Edwards, who was arrested Tuesday on drunken driving charges, will be part of the roster in Miami, although he will not start.
As well as Revis, linebacker Calvin Pace, who was hoping to return from a pre-season foot injury, will also miss the game.
"Calvin Pace and Darrelle Revis will not play in this game. Revis is not where he needs to be to play. We will leave him back, he will not make the trip to Miami," said Ryan.
"He will be getting all kinds of treatment, he has been having about 12 hours of treatment each day. He is itching to get back but it is too risky of a proposition to put him out there," he said.
Revis missed training camp and the pre-season games while holding out for a new four-year contract and the four-year NFL veteran said Wednesday that his absence was behind the injury he suffered in Sunday's win over the New England Patriots.
"Not being in camp is the reason I have the problem right now that I'm going through," Revis told Miami's WQAM radio.
Miami has won both its opening games while the Jets, long-standing rivals, lost to Baltimore in their season-opener game before bouncing back with an impressive 14-point win over the Patriots.
Ryan said that Edwards would not start at Miami but did not rule out him playing in the game.
"I made a decision to bench Braylon and any competitor will tell you that is a punishment," said Ryan.
Jets general manager Mike Tannenbaum told the team's website (http://newyorkjets.com) that any disciplinary action against Edwards would come after the case had been settled.
Tannenbaum said that the Jets have a 24-hour full-service security and driving company that covers players on trips to dinners, clubs and media and social events.
"Braylon is aware of this program and showed poor judgment," said Tannenbaum.
(Reporting by Simon Evans; Editing by Steve Ginsburg)