Ramires has completed his move to Chinese side Jiangsu Suning from Chelsea for a fee of £25m ($35.6m).
The Brazil international moved to Stamford Bridge from Benfica for £19.8m in August 2010 and went on to play 251 times for the Blues, scoring 34 goals in the process.
Ramires helped Chelsea win every major domestic and European trophy during his time at the club, although he was forced to sit out the Champions League final victory over Bayern Munich in 2012 after being booked in the semi-final against Barcelona.
The 28-year-old midfielder also featured in the Premier League and Capital One Cup double last season and only signed a new four-year contract in October.
He has found game-time harder to come by under new boss Guus Hiddink, though, and has not played in the Premier League since the goalless draw at Manchester United on December 28.
His last appearance for the club came in the 2-0 win over Scunthorpe in the FA Cup earlier this month.
He will now join up with former Chelsea defender Dan Petrescu, who is manager of Jiangsu Suning.
"Best of luck @Rami7oficial, thanks for the memories...," Chelsea tweeted after news of his departure broke.