St. Louis, MO – Chris Kunitz notched the winner in the fourth 2, at Scottrade Center.
James Neal and Steve Sullivan scored in regulation for the Penguins, who enter the All-Star break with seven straight victories.
Marc-Andre Fleury made 32 saves in regulation and stopped three of four chances in the shootout.
Patrik Berglund netted both goals for the Blues, who lost for just the third time in their last 10 games.
Brian Elliott played well in defeat, stopping 37-of-39 shots.
