New York, NY – Kris Joseph scored 20 points, Brandon Triche 58, Wednesday Off.
C.J. Fair added 12 points for the Orange, who moved on to face Stanford in Friday's title game.
Syracuse (5-0) didn't hold a lead until Fair's dunk with almost eight minutes gone in the second half made it 44-42. It was part of an 11-0 run that turned the game around.
Jarell Eddie scored 17 points to lead Virginia Tech (3-1) while Erick Green had 14 and Dorenzo Hudson added 13.
Stanford beat Oklahoma State, 82-67, in Wednesday's other semifinal.