Jackson also grabbed 12 rebounds for his 16th double-double for the Orange (20-4, 7-4 Big East), who've now won at least 20 games in 33 of 35 seasons under Jim Boeheim. His 849 career victories rank second among active Division I coaches behind Duke's Mike Krzyzewski.
The Orange built on momentum from a victory over No. 6 Connecticut that stopped a four-game losing streak, limiting cold-shooting USF (8-16, 2-9) to 35 percent shooting, including 2 of 15 from 3-point range.
Jarrid Famous led South Florida with 14 points. Toarlyn Fitzpatrick added 10 for the Bulls, who trailed 37-28 at halftime and didn't get closer than that nine-point deficit the rest of the way.