Wilson also had a rushing touchdown for the Razorbacks (5-1, 1-1 SEC), who have won two in a row since a loss to Alabama on September 24.
Arkansas wideout Joe Adams, who was listed as questionable for the game, had a big 92-yard rushing touchdown in the third quarter. He also caught six passes for 49 yards.
Jarius Wright hauled in five passes for 76 yards and a score. Dennis Johnson had three catches for 49 yards and a touchdown, while adding 42 yards on 12 carries.
Barrett Trotter completed just 6-of-19 passes for 81 yards and an interception for the Tigers (4-2, 2-1), who were coming off a thrilling 16-13 triumph over South Carolina on the road last week.
Kiehl Frazier connected on 2-of-4 passes for 18 yards and two interceptions. He also carried the ball 13 times for 54 yards and a score.
Michael Dyer led the way on the ground with 111 yards and a touchdown on 21 carries. Onterio McCalebb had 91 yards on 13 carries for Auburn, which racked up 290 yards on the ground.