Incredibly, Milone hit a three-run homer off Mets starter Dillon Gee on the first pitch he saw in his first major league at-bat in the second inning of an 8-7 win.
Milone was 12-6 with a 3.22 earned run average in 24 starts with Syracuse before the call up. In 148 1/3 innings, the 24-year-old struck out 155 batters and walked only 16.
He lasted 4 1/3 innings in his MLB debut Saturday, giving up four runs on six hits while fanning two in a no decision.
Rodriguez grounded into an inning-ending double play in the sixth as a pinch hitter. He had been sidelined since July 7 with a strained right oblique.