Orchard Park, NY – Chris Johnson carried the ball 23 times 17.
Johnson, who struggled early on this season, now has three 100-yard rushing performances in three of his last four games for the Titans (7-5), who remained two games behind red-hot Houston for first place in the AFC South.
Matt Hasselbeck completed 16-of-25 passes for 140 yards for Tennessee, which has won two in a row.
Ryan Fitzpatrick connected on 29-of-46 passes for 288 yards and a touchdown for the Bills (5-7), who have dropped five straight contests.
C.J. Spiller carried the ball 14 times for 83 yards and a score in defeat.
