Darron Thomas completed 13-of-25 passes for 169 yards and a touchdown for the Ducks (8-1, 6-0 Pac-12), who have won eight in a row since losing their season opener to now top-ranked LSU.
Kenjon Barner carried the ball 10 times for 41 yards and a score. David Paulson caught three passes for 65 yards and a touchdown.
Keith Price connected on 24-of-35 passes for 143 yards, two touchdowns and two interceptions for the Huskies (6-3, 4-2), who have lost eight straight against Oregon.
Chris Polk carried the ball 24 times for 80 yards and caught six passes for 31 yards. Kasen Williams hauled in six passes for 79 yards and a score.