It is the stiffest penalty handed down by new vice president of player safety Brendan Shanahan in his brief tenure.
The 27-year-old, who was acquired from Montreal in July and signed to a six- year contract worth a reported $33 million, will miss the final three preseason games and the first eight regular-season games for targeting the head of Minnesota's Cal Clutterbuck during last Friday's preseason game.
Wisniewski received a minor penalty for an illegal check to the head, and was suspended over the weekend, pending a review of the incident.
As a repeat offender, Wisniewski was docked $536,585.36 based on the number of games in the regular season (82), rather than the number of days (185).
Wisniewski already was held out of Sunday's exhibition contest, and will not be eligible to return until Columbus' October 25 tilt against the Detroit Red Wings.