Andrew Bogut scored 15 points and pulled down nine rebounds before fouling out. Stephen Jackson added 16 points and Jon Leuer chipped in 14 off the bench for the Bucks, who won their home opener after to falling to Charlotte Monday.
Kevin Love led all scorers with 31 points and 20 rebounds. Michael Beasley added 15 points and seven boards for Minnesota, which has dropped its first two games of the season.
The Bucks led by 10 with just under four minutes remaining before the T'Wolves cut it to 94-92, but the hosts proved to be too much.